The ratio between models with two and three background functions, H2 ζ / H3 ζ, is above 1 thus favouring the simpler model.
Numerical simulations are also performed to show the differences between the models with three and four bodies in the trajectories of the spacecraft.
However, at this stage, given the lack of certainty around the total sample size (and its distribution), it is perhaps appropriate to highlight that the method of analysis will involve fitting between group, repeated measures models with two levels of treatment variable (intervention group, control group) and three time points (T0, T1, T2) to the primary and secondary outcome measures.
Likelihood ratios were computed between the full model and models with two of the four disease-call subgroups collapsed, or with the two cell types collapsed, with the lme4 function 'anova'anova
In order to assess the association between an SNP and variability, mixed models with two different covariance structures were calculated.
Furthermore, calculating R-square values demonstrated that, the models with two parameters (i.e. Entropy, Prelec, and general hyperbola) had larger R-squre values than the simple hyperbola (which is a statistically trivial result), but no statistically significant difference was observed between the models with two parameters.
This was done by examining the difference in fit between models with a constant APC over the five periods with a model with a different trend in the early periods and later periods.
Covariates were considered in a stepwise manner, where the deviance information criterion 16 was used for choosing between models, with differences in the criterion of three or more considered to be important.
However, since the changes between the model with seven and eight profiles was very low, and because the proportion of students that could be assigned to the profiles with eight mixtures is very low for some conditional distributions, a latent profile model with seven mixtures is chosen.
The leukaemia risk predicted by such a model is equivalent to that resulting from a model with two pathways between the normal stem cell compartment and the final compartment of malignant cells, the second pathway having one fewer stage than the first.
