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Our study examines the relationship between microbial composition and metrics of these two efficiencies.
Given the functional importance of microbial community in biogeochemical cycling (Azam and Malfatti 2007), the linkage between microbial composition and function have received considerable attention.
Microbiome studies of human disease typically focus on correlates between microbial composition and disease phenotype at single or multiple points in time.
However, to fully understand the links between microbial composition and digester performance and adjustments in operating temperature and addition of trace elements further research is required.
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A significant association has been observed between commensal microbial composition and clinical response of anti-PD-L1 therapy in metastatic melanoma patients (Matson et al., 2018).
Several studies have reported a strong correlation between disrupted microbial composition and allergies and asthma.
However, this mechanism was contested by other studies which suggested that the relationship between the microbial composition and energy harvesting capacity is more complex than previously considered [ 74].
Consequently, the composition of obese microbiome is still questionable and more scientific evidence is needed to elucidate the relationship between the gut microbial composition and metabolic diseases.
In conclusion, we have observed a strong association between the gut microbial composition and the variation in BMI and blood lipid levels, which is independent of age, sex, and host genetics.
In the current study, correlations between fecal calprotectin, global fecal microbial composition, and genetic functional capacity were explored.
Even in this relatively straightforward example, interplay between environmental factors, diet, variable microbial composition and age must all be taken into account to understand host-microbiome interactions in human disease.
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