Sentence examples for between methylation and arsenic from inspiring English sources
Also, several CpG loci exhibited a linear dose-dependent relationship between methylation and arsenic exposure.
Most notably, our analysis identified cg08884395 and cg27514608, associated with genes ESR1 (estrogen receptor 1) and PPARGC1A (peroxisome proliferator activated receptor-γ coactivator 1-α), respectively, which both exhibited a negative association between methylation and arsenic exposure (linear trend p = 0.0009 for both).
Experimental models are needed to evaluate whether the connection between DNA methylation and arsenic metabolism and measures of body composition are related to muscle mass.
The correlations between p53 promoter methylation and arsenic accumulation in nails were determined by Pearson correlation coefficient.
Both DNA methylation and arsenic metabolism require S-adenosylmethionine (SAM) as the methyl donor.
However, no significant differential methylation or any correlation between methylation and sgVtg expression levels was observed.
Although our sample size was limited, we found statistically significant associations between urinary cadmium concentrations and global DNA methylation and between arsenic metabolism (measured as %DMA) and global DNA hydroxymethylation.
Additional research on dose response relationships between arsenic methylation and chronic health effects, as well as further information on the environmental and genetic factors that control arsenic methylation, may help in the identification of susceptible subpopulations and could provide important insights into the carcinogenic mechanisms of this common drinking water contaminant.
We used general linear models to evaluate the relationship between DNA methylation and tertiles of arsenic exposure.
The findings of this study suggest new genotype phenotype links and additional mechanistic studies are necessary to elucidate the precise mechanisms of these interactions between GSTT1 and arsenic methylation capacity.
The relationship between creatinine and arsenic methylation has been reported previously as an aside, without noting that it is the most important predictor nor being able to compare it with multiple nutritional factors as we have done here.
