Sentence examples for between methotrexate toxicity and from inspiring English sources

Borderline associations (P>0·01 to ≤ 0·05) were detected between methotrexate toxicity and two SNPs in ATIC.

A total of 48 had methotrexate-resistant disease, eight had severe methotrexate toxicity and an empirical decision to change treatment was made in three.

We identified additional candidate genes from publications by using a PubMed search with key words "methotrexate", "toxicity," and "polymorphism".

This suggests methotrexate toxicity and pharmacokinetics in chemotherapy may be secondary to its effects on cellular abilities to buffer oxidative flux via non-DHFR mechanisms.

Multivariate analysis accounting for age at onset of psoriasis, sex and ethnicity showed four borderline associations between three SNPs in ATIC and one in FPGS and methotrexate toxicity.

Although we identified only three QTL using our model and criteria for significance, we likely missed many more genes known to be involved in the methotrexate pathway and methotrexate toxicity.

An example is the interaction at OATs between nonsteroidal anti-inflammatory drugs and methotrexate that can result in severe methotrexate toxicity (Uwai et al. 2000).

The influence of 7-OH methotrexate on methotrexate toxicity was investigated by studying cell growth in the presence of methotrexate and its 7-OH metabolite and by studying [3H]-methotrexate movement across the plasma membrane of isolated human cells.

These data suggest that an estimated creatinine clearance of less than 79ml/minutee increases severe methotrexate (pulmonary) toxicity and that hypoalbuminaemia is associated with methotrexate-induced thrombocytopenia, liver and pulmonary toxicity.

Methotrexate toxicity mechanisms are not yet fully identified but many assumptions might explain this neurotoxicity, like interference of Methotrexate with transmethylation reactions that are important for the formation of lipids, myelin and proteins [8].

Prevention of nephrotoxicity, together with methotrexate level monitoring, is crucial to prevent extrarenal methotrexate toxicity.