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As we stated, there is no difference in outcome between methods of detection for axillary relapse or contralateral cancers.
If all sites of relapse are analysed together, as Maraqa and Lansdown correctly point out, there is no difference between methods of detection of relapse, although this was not presented in our paper.
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There was no association between method of detection of relapse and survival in patients who developed a new contralateral breast cancer.
There was similarly no association between method of detection of recurrence and survival in patients who had isolated ipsilateral axillary relapse, although the numbers overall were small.
19, 20 The association between method of detection and the sentinel node identification is notable, showing a higher detection rate with the combined method (radioactive tracer and blue dye).
Furthermore, no correlation could be found between the methods of detection and the number of positive nodes, lymph node size, or extranodal growth.
Montgomery's [ 19] own study showed a poorer survival for clinically detected cancers while the Dutch [ 23] and Hong Kong [ 24] studies found no difference in survival between different methods of detection but numbers involved were smaller than in the meta-analysis by Lu [ 16].
As stated, when analysed separately, there was no difference between the three methods of detection for either site of relapse.
There were statistically significant differences in M. bovis detection between methods of extraction and types of environmental samples; no significant differences were observed between operators.
An important difference between our study and that of Colombrita appears to be the methods of detection.
And Brother Chris has a number of additional methods of detection.
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