Moreover, six separate correlation analyses (Pearson Product Moment test) were performed between memory measures for enacted and observed items on the three experimental tasks (Free Recall, Recognition and Source Memory) and ToM ability, as assessed by the Faux Pas task.
An association between verbal memory measures and residual hippocampal volume was seen, most clearly after left temporal surgery.
We provide evidence to support the link between performance on episodic memory measures and hippocampal volumes in a memory clinic population, and we assert that measures of non-verbal memory may have higher diagnostic value, particularly in individuals at higher risk for development of AD (i.e., amnestic MCI), which represents a target for future research.
Better characterization of the relationship between commonly used episodic memory measures and hippocampal volumes is crucial, as it may assist in efforts at early detection of neurodegenerative disease and may suggest new biomarkers for use in clinical trials of AD therapies.
Data were analyzed to examine relationships between performance on the episodic memory measures and hippocampal volumes.
Positive associations were identified between bilateral hippocampal volumes and both memory measures, and BVMT-R learning slope was more strongly positively associated with hippocampal volumes than HVLT-R learning slope.
In the current study, we examined associations between hippocampal volumes and memory performance in a large, heterogeneous memory clinic sample, using commonly-used memory measures and an FDA-approved automated neuroimaging analysis tool.
Significant prospective relations were found between working memory measured at Time 1 (T1) and both primary and secondary control coping measured at T2, controlling for T1 coping.
Future studies should examine the relationship between hippocampal volume and specialized memory measures, as well as between depression diagnosis and volume of other brain structures.
