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Previous studies [ 7, 24] also showed the correlation between lymph node involvement and distant organ recurrence.
Additionally, there is also a positive relationship between lymph node involvement and CXCR4 staining of these subtypes [ 30].
In our study, the analysis of correlations between lymph node involvement and CXCR4 expression was not applicable due to limited cases (n=6).
In various cancers, a positive correlation was revealed between VEGF serum levels and tumor size, as well as between lymph node involvement and the presence of metastases [ 26].
When the Cox model was applied, the relationship between lymph node involvement and doubling time was significant, as was the interaction term.
Associations between lymph node involvement and mean lesion stiffness, invasive cancer size, histologic grade, tumour type, ER expression, HER-2 status and vascular invasion were assessed using univariate and multivariate logistic regression.
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However, the association between S100P and lymph node involvement was only significant for ER− tumours (P=0.010).
However, no significant association was observed between haplotypes and lymph node involvement, tumor size, C-erbB-2 or P53 statuses.
The correlation between metastatic axillary lymph node involvement and the presence of Met in the lymphatic fluid is shown in Table 2.
Our observations were confirmed on protein level as well and the association between Nampt/PBEF/visfatin and lymph node involvement in particular was further supported by significant elevation of circulating cytokine in N-positive CRCs.
There was no significant difference in cancer cell FAK scores between tumours with and without lymph node involvement or between tumours with positive and negative Her2 status.
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