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By applying MEGA, we can find possible molecular links between lymph node invasion and cancer prognosis in human breast cancer, supported by evidences of feasible gene expression patterns and significant results of meta-analysis tests.
If we found a candidate gene set which connects gene expression changes and lymph node invasion (A in Figure 7), it should be able to explain the relationship to cancer prognosis (C in Figure 7), because the correlation between lymph node invasion and cancer prognosis has been firmly proven (B in Figure 7).
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The relationship between ddCTC and lymph node invasion suggests that blood is a major dissemination route.
We found an interesting relation between plasma MMP8 levels and lymph node invasion or the risk of distant metastasis.
There was a relationship between ddCTC positivity and the absence of lymph node invasion p = 0.050, (risk = 5%) and values of Adjusted R 2 had a significance level for = 0.05.
Based on several studies showing a relation between positive peritoneal cytology and unfavourable prognostic factors (lymph node invasion, grade, myometrial invasion, etc).
No relationship were established between timing of surgery (during versus after pregnancy), hormone receptor status, lymph node invasion and number of foetal cells.
Lymph node invasion represents bad prognosis.
Detection of lymph node invasion is performed by CT-scan and RMI, which show hypertrophied nodes.
Lymph node invasion is the first step of metastatic evolution of prostate cancer.
However, none of these trials included patients with lymph node invasion (LNI).
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