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Furthermore, the relationship between lung function abnormalities (yes or no, according to interpreted lung function tests) and the AUC CV > CVT) value was assessed in the same manner; but in this case, both healthy subjects and patients were included.
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However, in contrast to other studies, 10 we did not find a significant association between ACPA and RF and lung function abnormalities, but a trend between RF at baseline and OLD and a trend between ACPA at baseline and RLD at 15 years was observed.
Use of steroids at the time of the 15-year assessment was associated with RLD, but use of methotrexate did not differ between patients with lung function abnormalities and those without.
Lung cystic involvement correlates with lung function abnormalities and predicts functional decline.
The results of thorough lung function tests were interpreted as normal, with or without early signs of lung function abnormalities.
Patients with lung function abnormalities, according to lung function tests, generated higher AUC CV > 20%) values compared to healthy subjects (p = 0.006).
The results suggest that our present SPECT method has the capacity to identify minor lung function abnormalities earlier in a disease process than conventional lung function tests.
Affected infants can suffer chronic respiratory morbidity including an excess of respiratory symptoms and lung function abnormalities even in adulthood.
Lung function abnormalities, both at rest and during exercise, are frequently observed in patients with chronic heart failure (HF), also in absence of respiratory disease.
Finally, the highest AUC CV > CVT) values were found in the subject with signs of lung function abnormalities (subject S12) and in the two patients (P1 and P2) who had documented lung diseases.
This work explores the potential advantages of quantitative heterogeneity measurements by performing a pilot study of the CV measurements with healthy human subjects, i.e. those without documented lung disease, respiratory symptoms or lung function abnormalities.
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