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Our observed association between lower expression of POR and the three PAR bZip genes; Dbp, Tef and Hlf, and the higher liver/body weight ratio in SPF are consistent with results from hepatic POR null mice [27] and PAR bZip triple knockouts [23] where the liver/body weight ratios are increased, most likely because of accumulation of lipids.
These results showed some correlation between lower expression of lamin A/C or nesprin-2 and disease-free survival, whereas we did not observe statistical significance for either lamin A/C or nesprin-2 expression in both analyses (Fig. S2 and data not shown).
The significant prognostic effect of high miR-375 expression in this study with obvious heterogeneity possibly led to the negative statistical results in some subgroup analyses, including data extrapolated, univariate analysis, and blood-source of miRNA: in these subgroups, there was no association between lower expression of miR-375 and poor prognosis.
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These results suggest a direct correlation between the lower expression of telomerase and the impaired caudal fin regeneration in older fish.
In our study a correlation was found between higher histological grade and lower expression of miR-199b and miR-99a.
However, there was no difference in the incidence of venous invasion and advanced tumour-node-metastasis staging between patients with higher and lower expression of FAK.
The same group previously identified a correlation between the A allele of rs172378 with lower expression of the C1QA protein (Racila et al, 2003).
Even though we report no difference in collagen-stained area between the two groups, we measured significantly lower expression of the CTGF, indicating a lower turnover of the collagen in the aneurysms.
Knockout of IAPP gene expression resulted in lower expression of Calcr and RAMP3 receptors.
The between-culture differential expression of TLR4 was confirmed and extended by quantitative PCR analysis (QPCR) that revealed a 33-fold lower expression of TLR4 in the LRarray fibroblast culture.
Lower expression of IAPP corresponded with higher degenerative degree (Figure 1a).
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