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We found no significant bivariate association between low ferritin levels and any of the blood disorders investigated.
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More recent studies have not shown sufficient evidence of the relationship between low ferritin level and FPHL and do not recommend iron supplementation in the absence of deficiency anemia [ 60].
The association between FPHL and low ferritin levels was suggested in two different studies [ 58, 59] which reported significantly lower ferritin levels in women suffering from FPHL compared with controls.
Moreover, we compared clinical findings between SLE patients with low ferritin levels and SLE patients with high ferritin levels (Supplementary Table 2, available on the Arthritis & Rheumatology web site at http://onlinelibrary.wiley.com/doi/10.1002/art.38672/abstract), and found differences in serum liver enzyme and CRP levels between the 2 groups.
Patients had raised transferrin (median 2.60 vs. 2.16 g/l, p = 0.001) and low ferritin levels (34.9 vs. 119.0 g/l, p< 0.001) indicating relative iron deficiency.
6 H. pylori was also associated with low ferritin levels.
Ferritin and haemoglobin levels had a weak positive association, with the effect more pronounced at very low ferritin levels.
Serum AST, LDH, and CRP levels were significantly higher in patients with high ferritin levels than in patients with low ferritin levels.
Serum levels of AST, LDH, and CRP were significantly higher in patients with high ferritin levels than in those with low ferritin levels.
Although anemia prevalence differed by α+-thalassemia genotype, the prevalence of low ferritin levels did not.
Since serum ferritin is a more specific and early indicator for iron deficiency anaemia, the low ferritin levels with stable serum iron concentrations suggest reduced body iron capacity.
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