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As discussed previously, the association between low Hcy levels and worse outcome may be explained by malnutrition in HD patients.
We confirm a similar association in the crude analysis between low Hcy levels and a higher mortality risk.
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The associations of decreasing albumin levels as well as low Hcy levels with worse outcome reflect protein-energy wasting.
As increased expression of DYRK1A and low plasma Hcy levels have been associated with DS [6], [11] [13], we also analyzed the contribution of DYRK1A on Hcy levels in a mouse trisomic complex, the Ts65Dn mice.
On the other hand, an increased expression of DYRK1A and low plasma Hcy levels have been associated with DS [6], [11] [13].
Galletti et al. also demonstrated that the intracellular concentration of SAH is significantly reduced in DS erythrocytes, paralleling the low plasma Hcy levels, and the intracellular SAM concentration is the same as in the control cells [13].
We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period.
As we found a negative correlation between plasma Hcy levels and hepatic DYRK1A expression which underlines the effect of hyperhomocysteinemia on DYRK1A expression [10], we decided to analyze the over-expression of DYRK1A on Hcy metabolism.
We previously observed a negative correlation between plasma Hcy levels and hepatic DYRK1A expression, which emphasizes the effect of hyperhomocysteinemia on DYRK1A expression [10].
Furthermore, a recent study by Zoccolella et al. on PD patients reported a correlation between increasing Hcy levels and LID [48].
Recently our group demonstrated a significant association between elevated Hcy levels and the presence of NVAF, suggesting a role for HHcy as new factor involved in the pathogenesis of atrial fibrillation [9].
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