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However, a multisite trial also carries risks, the most important one being lack of equivalence between local study populations.
A multisite trial has the advantage of being efficient, but it also carries risks, the most important one being lack of equivalence between local study populations.
Variations between local study populations are not an insurmountable barrier for pooling data across sites, if they somehow can be accounted for [ 7, 8].
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The study was reviewed and approved by local institutional review boards with jurisdiction over local study populations.
The study protocol was reviewed and approved by local institutional review boards that had jurisdiction over the local study populations.
The study was reviewed and approved by the local institutional review boards that had jurisdiction over the local study population.
There were differences between study populations.
Possible overlaps between study populations were considered.
Nevertheless, the present study suggests that, despite the potential for high connectivity between local populations of invertebrate species with planktotrophic larval development within the Portuguese margins, some local constraints to gene flow among populations of C. maenas may exist, at least during the time period in which sampling was undertaken.
Hence, the difference between the two studies may be a consequence of differences in demographic history between local populations versus the species as a whole.
Altogether, the differential expression of genes in environmental studies indicates that the genes that are important for the variation between local populations of C. elegans are indeed of significance for interactions with the environment.
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