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To our knowledge, correlation between levels of gene hyper- and hypomethylation has not been reported before.
Several studies conducted in organisms as diverse as humans, Drosophila melanogaster and Caenorhabidtis elegans, have demonstrated that there is an inverse relation between levels of gene expression and a variety of sequence parameters such as the length of coding sequence, intron number and length [1] [3].
To do so, we examined the absolute levels of transcription, histone acetylation and DNA methylation for all subjects combined (Fig. S3), and compared them to previously published relationships between levels of gene expression, DNA methylation, and histone acetylation across 5' regulatory regions, exons, and introns.
We next examined the relationship between levels of gene expression and prevalence of somatic mutation.
However, the interpretation of the relationship between levels of gene expression and sex bias is not straightforward.
We observed very strong correlations for all studied species between levels of gene content variation and levels of gene sequence variation.
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d Spearman's correlation between level of gene expression and ω estimated along the two Cardamine lineages.
Accordingly, there was no correlation between level of gene expression for either hGH receptor or prolactin receptor and CIS gene expression across these lines.
The lack of a perfect correlation between levels of ZmRap2.7 gene expression and genotype (and methylation state) at Vgt1 is likely due to the complexity of ZmRap2.7 gene expression regulation.
The markers described in this study will be useful for evaluating genetic diversity within and between populations, levels of gene flow, and the population dynamics of clones.
The correlation between the levels of gene expression and methylation in tDMCs was calculated by the Pearson's correlation test.
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