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In osteoporosis, a clear relationship has been established between levels of bone markers such as Ntx and the occurrence of skeletal complications, whether or not a patient has received bone-specific therapy.
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We compared the serum biomarkers between groups with normal and low BMD and assessed the correlations between the levels of bone turnover markers and the lipid profile and hsCRP level.
At baseline there were no significant correlations between the levels of bone markers and baseline BMD at either skeletal site.
Our research confirmed the significant negative correlation between the levels of bone turnover markers with BMD and T-scores at various skeletal sites in native Chinese women; in other words, the BMD and T-scores decreased as the levels of various bone turnover markers increased.
Interestingly we were not able to detect any clear association between levels of ACPA and bone destruction.
a significant correlation (r2 = 0.95) between levels of adducts in bone marrow and white blood cells was observed.
Many studies have shown a correlation between increased rates of bone loss and increased levels of bone turnover markers [ 5- 16].
We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study the effect of changes in the levels of bone turnover markers on the risk of osteoporosis.
A close correlation existed between levels of VEGF production and the amount of newly formed bone.
There was a correlation between ln FGF23) and the levels of bone-metabolism-related markers (Table 2).
A balance between levels of osteoprotegerin and of the receptor activator of the nuclear factor-κβ ligand (RANKL) is important in bone pathophysiology and it is a drug target in the treatment of bone metastases and osteoarthritis.
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