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Exact(11)
At developmental stages E11.5 (data not shown) and E15.5, no differences between knockout and control animals were evident.
Similarly, expression of anorexigenic genes, POMC and CART, was not different between knockout and control mice.
In addition, histological analysis revealed no discernable skeletal muscle structural abnormalities between knockout and control mice.
If such differences in gene expression profile are detected between knockout and control, these are probable parts of the same biological subsystem.
We found 15 probesets with very strong evidence for an expression difference between knockout and control mice, one of which represents Cckbr itself.
In response to this concern, we also went back and re-quantified more sections and the conclusion of no significant differences in the numbers of CTIP2+ cells in layer 5 between knockout and control held.
Similar(49)
In our normalization, there is still a chance to be significantly different in very low intensity but in a large ratio between knockouts and controls stochastically.
No differences were observed between Cebpd knockout and control mice with respect to the size of their first litters (Fig. 5A).
DOI: http://dx.doi.org/10.7554/eLife.02510.017 10.7554/eLiFigure10.018 Figure 4 figure supplement 2. Differences in detected rhythmic transcripts between Dicer knockout and control are not caused by too low stringency rhythm detection.
(C ) The distribution of the change in mRNA/pre-mRNA ratio between Dicer knockout and control is globally similar for rhythmic transcripts as compared to all transcripts.
To delete Lsd1 in vitro, we added interferon alpha (IFNα) to control and Lsd1fl/fl Mx1culturesures, and although colony numbers were comparable between Lsd1 knockout and control, stark differences in colony and cell morphology were observed.
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