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Others have reported the longitudinal relationship between joint damage and physical function after adjustment for disease activity.
Prospective studies of the links between joint damage and functional disability are scarce and discordant in part, so the association between damage and disability remains uncertain.
However, the recent reports demonstrating a close relationship between joint damage and MSU crystal deposition emphasize the importance of strategies to reduce crystal burden before structural damage occurs.
The objectives of this study were to determine the predictive factors of long-term radiographic outcome of rheumatoid arthritis (RA) and to describe the relationship between joint damage and disability over the course of the disease.
Correlations could be identified between joint damage and gait changes in MCLT + MMT animals; however, the same gait changes were found with MCLT sham animals despite a lack of joint damage.
In future studies, more sophisticated statistical correlation models may assist in identifying relationships between joint damage and behavioral changes, and assessment of changes in sensitivity, rather than raw sensitivity, may improve these correlations.
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17 Although previous results are suggestive of an interconnected association between joint damage, physical function and employment status, 19 32 33 the relative contribution of JE and JSN progression to employment status has not yet been evaluated.
5 Thus, although a correlation between OA joint damage and pain can be found, there is often discordance between the degree of structural change and the severity of pain, so disease severity defined exclusively by structural degeneration is inadequate.
The consequences of persistent synovitis in terms of disrupting these functions are well documented for established RA [ 8- 13] but the association between joint damage in the feet, impairment and function has not been evaluated in early disease.
In these post hoc analyses, no clear relations between radiographic joint damage and biomarkers were found.
Importantly, however, a similar correlation was seen between progression of joint damage and composite measures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com