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The gene was considered differentially expressed if this p-value was <0.05 and the ratio between its expression level in the case sample and the average expression in the controls was at least 1.4.
Each gene was assigned a growth correlation score (GCR), quantifying the correlation between its expression level and growth rate, averaged over all perturbations.
Specifically, we assigned each gene a growth correlation score (GCR), quantifying the correlation between its expression level and growth rate, averaged over all perturbations (Methods).
In every sample, as the ratio between its expression level and that of the host gene.
For each gene represented on the array, we calculated the Pearson correlation coefficient between its expression level at each time point and the ordinal time value.
The present study was designed to investigate the role of this protein in prostate cancer, focusing on the correlation between its expression level with tumor differentiation and response to treatment.
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Although the exact reasons why the correlation between miRNA stability and its expression level is negative keep unknown, it is reasonable to propose that the miRNAs with "rapid production and rapid turnover" may mainly implicate in biological processes of cellular status-transition.
However, for a specific miRNA, the relationship between its stability and its expression level across various cell types remains unknown.
In the above analysis, we revealed a negative correlation between miRNA stability and its expression level, a distinct mode of miRNA action that may be determined by the special role of miRNAs in the negative regulation of target genes.
Strikingly, the result revealed negative and not positive correlations between miRNA stability and its expression level (Table 1), which is different from other known biological molecules such as protein, mRNA, and noncoding transcript.
Also, there was no statistically significant correlation between serum chemerin level and its expression level in EAT (P > 0.05).
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