Sentence examples for between immune complex and from inspiring English sources

These observations suggest a possible link between immune complex and ANCA in a subset of glomerulonephritis.

This case may confer valuable information regarding the link between immune complex and ANCA-associated CGN.

Fcγ receptors (FcγRs) play a pivotal role in the reaction between immune complex and myeloid cells.

Because high titres of these antibodies (IgG, not IgM) were also detected in healthy individuals, the arthritogenicity of these antibodies should be due to modulation – by the low affinity genotype of FcγRs – of the bypass between immune complex and FcγR bearing cells.

The interaction between immune complexes and FcγRs might therefore be involved in the pathogenesis of some arthritic conditions.

Its precise function in the immune system remains to be clarified but there is accumulating evidence that it plays a role in the interaction between immune complexes and neutrophils [ 11- 13].

The lack of effect of u-PA deficiency with these stimuli therefore gave us the opportunity to once again see whether there is a particular association between immune complexes and u-PA.

Specifically, initial contact between immune complexes and macrophages results in cellular regulation: plasma complement-independent C5a production; selective Gi-dependent C5aR signaling; and C5aR-Gi-mediated FcγR alterations towards Fc RIII, the previously shown main inducer of tumour necrosis factor alpha and CXCR2 ligand production.

Although interactions between immune complexes and cellular receptors for the Fc regions of IgG (FcγR) were not considered in earlier clinical investigations of RA, the recent characterization of these receptors and the availability of relevant murine model systems has permitted a thorough examination of their impact on pathogenesis.

In light of our recent findings of increased MMP activity and qualitative changes in collagen IV expression within glomeruli of lupus-prone mice during the development of nephritis, this scenario provides an attractive model to explain the relationship between immune complex deposits and renal dysfunction.

Our study shows that there are important differences between immune complex-induced inflammation in the brain and other tissues, but highlight the similar role for FcγRs in the initiation of IgG-mediated inflammation and functional behavioural changes.