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The association between higher doses of CMS and higher colistin plasma concentrations suggest that this polymyxin has linear pharmacokinetics.
Nevertheless, when prescribing this drug clinicians should consider the association between higher doses of acetazolamide and the increased risk of adverse effects, particularly paraesthesia.
The dose-dependent effect of insulin glargine supports the finding of a potential link between higher doses of insulin glargine and incidence of cancer reported in a case control study by Mannucci et al [ 13].
However, there was no statistically (ANOVA) significant relationship between infection rates and any diagnosis; although, there was a significant relationship between higher doses of rituximab and a reduced rate of infections (Poisson regression model).
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A number of observational studies reported association between higher dose of dialysis as measured by Kt/V urea or urea reduction ratio with lower mortality risk.
Multivariate analyses have established the correlation between higher dose of contrast media and risk for CI-AKI [ 42].
American researchers say they have confirmed a link between high doses of some over-the-counter medicines and dementia.
Recent studies have suggested a causal association between high doses of green tea-containing dietary supplements and liver damage [9].
This is in line with previous reports showing no correlation between high doses of vitamin D2 and circulating levels of cathelicidin [20].
A recent study by Stevens et al. 43 found no association between high doses of (OROS) MPH with unusually elevated plasma concentration of MPH or clinical toxicity.
In addition, while the association between high doses of ionizing radiation and leukemia is well established [ 15, 16], the evidence for low dose sources such as diagnostic X-rays is evolving.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com