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American researchers say they have confirmed a link between high doses of some over-the-counter medicines and dementia.
Recent studies have suggested a causal association between high doses of green tea-containing dietary supplements and liver damage [9].
This is in line with previous reports showing no correlation between high doses of vitamin D2 and circulating levels of cathelicidin [20].
A recent study by Stevens et al. 43 found no association between high doses of (OROS) MPH with unusually elevated plasma concentration of MPH or clinical toxicity.
A recent study has shown an association between high doses of warfarin in CYP2C9 extensive metabolisers carrying the non-synonymous EPHX1 SNP rs1051740 which results in a tyrosine to histidine substitution at residue 113 (Loebstein et al. 2005).
23 Building on previous research that demonstrated inverse associations between high doses of utility cycling and mortality, we used data from a large population-based cohort to examine associations between more modest levels of cycling and mortality.
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The association between higher doses of CMS and higher colistin plasma concentrations suggest that this polymyxin has linear pharmacokinetics.
Nevertheless, when prescribing this drug clinicians should consider the association between higher doses of acetazolamide and the increased risk of adverse effects, particularly paraesthesia.
The dose-dependent effect of insulin glargine supports the finding of a potential link between higher doses of insulin glargine and incidence of cancer reported in a case control study by Mannucci et al [ 13].
However, there was no statistically (ANOVA) significant relationship between infection rates and any diagnosis; although, there was a significant relationship between higher doses of rituximab and a reduced rate of infections (Poisson regression model).
A number of observational studies reported association between higher dose of dialysis as measured by Kt/V urea or urea reduction ratio with lower mortality risk.
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