Your English writing platform
Discover LudwigSuggestions(1)
Exact(1)
The affinity of A1HC17 and A1HC38 were measured and were equal to 4.79 and 1.9 nM, respectively, and it is interesting to note that no strict correlation between high affinity and neutralization properties was observed; in fact the four scFvs with the highest affinities were not neutralizing.
Similar(59)
Although the initial observation was a correlation between higher affinity and reduced receptor agonism, further analysis showed a clearer correlation between a slower rate of dissociation and reduced agonism.
One example is represented in the 'competition model', where there might be competition between high-affinity and low-affinity proteins for binding to the EGFR.
There does not appear to any clear relationship between high affinity receptor and peak response magnitude.
For electrochemical measurements a ligand with n=3, bound only by its (oxidized) isoalloxazine moiety, appeared to be the best compromise between high affinity binding and short ET distance.
Although high uptakes of Affibody molecules have been obtained in tumors due to a favorable balance between their high affinity and smaller size compared to antibodies and fragments, [33] hypoxia and collapse of vessels due to increasing pressure would clearly contribute to a disparity between the total receptor levels and those measured by the in vivo imaging tracers.
A link between higher affinity for self-pMHC and residence within the CD4+ T-cell memory pool of adult mice was previously reported (Mandl et al., 2013).
This small difference may indicate the difference between high-affinity binding and mixed-affinity binding.
Furthermore, FcγRs can be distinguished between high-affinity receptors (FcγRI) and low-affinity receptors (FcγRII and FcγRIII).
Taken together, a significant reduction in the high-affinity K+ transport activity due to dysfunctional mutations in the SOS1 gene in Arabidopsis plants implicates a complex interaction between high-affinity K+ uptake and Na+ extrusion in roots as has been observed in roots of cereals (see above), which remains to be elucidated.
A similar relationship between high-affinity iron uptake and sensitivity to oxidative stress has been observed in yeast [ 15].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com