Sentence examples for between high PrP levels from inspiring English sources

Moreover, a statistically significant association was observed between high PrP levels and metastatic events (Table 1).

To evaluate if ER stress is associated with high PrP levels, we investigated the ER stress marker BiP (also known as GRP78) and PrP levels in breast cancer TMA by immunohistochemistry. PrP was detected in the cytoplasm and in the nucleus of epithelial cells, infrequently found at the cell surface of epithelial cells and was absent in stromal cells.

The high BiP-expressing tumor cores had higher PrP levels than low BiP-expressing tumors indicating that ER stress is associated with increased PrP in these tissues.

These results indicate that higher PrP levels are associated with a poor outcome in breast cancer.

Our TMA analyses of human breast carcinomas showed that (a) high ER stress marker BiP levels were associated with higher PrP levels, (b) both BiP and PrP levels were higher in grade 3 tumors compared to grade 1 tumors, and (c) levels of PrP correlate with estrogen and progesterone receptor negative tumors.

The MDA-MB-231 and HS578T cell lines have intrinsic ER stress activity based on higher levels of ER stress-regulated BiP and correspondingly have much higher PrP levels than the MCF-7 and HCC1500 cell lines.

Together, these results indicate that high PrP mRNA levels are associated with poorer prognosis breast cancers.

The high PrP mRNA levels were associated with a poorer prognosis and with the acquisition of a basal phenotype, which is associated with poor patient survival.

In contrast, splenic PrPC immunolabelling showed that many cells in the red pulp expressed PrP weakly suggesting that the relatively high PrP mRNA level in the red pulp compartment was the result of a relatively low single cell expression in a broad group of cells.

We compared CWD transmission in Tg(CerPrP-E226 5037+/– CerPrP-E226 5037+/+/– mice, which express PrP andlevels ≈5-fold higher Tgan PrP levels in wild type mouse brain, and found that CerPrP 1536+/ion was consistently and substantially mice rapid in Tg(CerPrP-E226)5037+/– mice.

High prion protein (PrP) levels are associated with breast, colon and gastric cancer resistance to treatment and with a poor prognosis for the patients.