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The Fisher z-test used in dcGAIN is designed to find correlation differences between groups, which made it better than reGAIN at finding the differential co-expression effects constructed in our simulations.
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The former remark was made in the context of rejecting the null hypothesis at the 5% level for significance and the latter presumably implied that mean t-statistics and z-scores were compared between groups, which makes no statistical sense.
Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors.
However, change was reported for each group separately and not compared between the groups, which make it difficult to know the effect estimate for use of each drug group.
The null distribution was obtained by permuting subjects' data between the groups, which makes use of the null hypothesis of no effect of group membership on BOLD signal, and refitting the linear model.
The binarization criteria varied, of course, between the study groups, which makes a comparison of the absolute values of the FDs rather difficult.
Besides that, nowadays there is also much interest in using multilevel modeling to explain differences between individuals and groups, which makes it even more important to use unbiased estimates for the variance parameters.
A particular strength of this study was the evaluation of an ambitious quality improvement initiative with a direct comparison between two naturalistic groups, which makes the study appropriate to be included in an evidence review of quality improvement interventions [ 39].
I was talking to a colleague, one of ten black women partners at a well-known investment bank out of over a thousand partners worldwide, who added the following insight that I also see as relevant to my experience as a white woman investor: Being one in a thousand also means that you're constantly used to navigating the distance between yourself and other groups, which makes you a better investor.
Further, regardless of the etiology of CKD, there was no difference in diastolic and systolic blood pressure between frail and non-frail groups, which makes the influence of hypertension on frailty inconclusive.
After the addition of cyclodextrin, the inclusion complex can be formed between cyclodextrin and ferrocene (or azobenzene) pendant groups, which makes the amphiphilic copolymers hydrophilic and triggers the chain unfolding of the nanoparticles in aqueous system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com