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Additionally, a survival regression model was fit with terms for interaction between group and round.
The interaction term between group and round was not statistically significant (at the α = 0.05 level of significance) for either the scale parameter (p = 0.06) or the shape parameter (p = 0.49).
The increase in bacterial burden within the spleen was consistent for all groups and the ordering of groups by bacterial load was preserved from round 1 to round 2. The interaction term between group and round was statistically significant (p<0.01) for bacterial burdens in the lungs.
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The main effects in the MANOVA were group and round, and an interaction term between the two was also included to determine if the group effect was consistent between rounds.
We recently tested this question with a public goods game, a type of experiment often used to study the conflict between group and self-interest., Over 12 rounds, six participants recruited from the same class could choose to invest a certain amount of their allotted capital, endowed to them at the start of the game, into a common pool or keep it.
Based on the difference-in-differences estimate (interaction term between study group and study round), the increase in uptake of FP in the intervention sites was significantly lower (OR = 0.6; p < 0.01; 95 % CI: 0.4 0.8) compared to the comparison sites.
The difference in the changes in uptake of PITC between intervention and comparison sites at baseline and 15-month follow-up (i.e., the difference-in-differences estimate, as denoted by the interaction term between study group and study round) was not statistically significant.
We did not find any evidence of interaction between IPTi drug group and IPTi round (i.e. there was no suggestion that efficacy of IPTi compared to placebo varied between the different rounds), but it would be preferable to have greater precision to look at separate rounds in isolation.
The models also included an interaction term between the study group and study round (coded as 1 = 15-month follow-up and 0 = baseline) to assess the difference in the changes in uptake of PITC and FP services between intervention and comparison sites over time (that is, the difference-in-differences estimate).
There's one other significant change between group play and the knockout round, though, and that involves the schedule.
Future studies should estimate the prevalence of diarrhoea in the dry season, or for an entire year, to determine if these differences between groups occur year round.
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CEO of Professional Science Editing for Scientists @ prosciediting.com