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Such a mechanism can explain the link between glucose uptake and AMPK stimulation and allows an increased glucose uptake without increasing intracellular metabolite levels and glucotoxicity.
In order to determine the relation between glucose uptake and glycemia as well as a possible effect of EMD008, the measured flux data were analyzed using a mathematical model based on the assumption that these flow rates are directly closely linked to the plasma glucose availability (conc) and the AMPK activation (ampk).
Downstream of glucose transport and glycolysis, mitochondria OXPHOS acts as a link between glucose uptake and ATP generation.
Several hypotheses have been postulated for causing overflow metabolism of acetate, mainly involving imbalance between glucose uptake and TCA cycle or energy and biomass generation throughput [ 44, 47].
To obtain quantitatively accurate predictions, one must first understand the relationships that exist between glucose uptake and biomass composition with the SPF.
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Interestingly, among the enzymes between the glucose uptake and the BDO pathway, the enzymes belonging to the lower branch of TCA cycle have been identified as the most important for improving BDO production and yield.
To assess the relationship between myocardial glucose uptake and metabolic parameters, univariate analysis was performed (Table 2).
Pearson's correlation coefficients were calculated to examine the relationships between myocardial glucose uptake and metabolic variables.
Besides the staging implications of this new instrument, particular attention has recently been focused on the possible correlation between neoplasms glucose uptake and other biological parameters predictive of tumoural aggressiveness.
In addition, we did not assess cardiac function in our participants; therefore, possible correlations between myocardial glucose uptake and cardiac function would be an important topic for future studies.
These metabolic disturbances may lead to diabetic cardiomyopathy, however, further studies of the relationship between myocardial glucose uptake and cardiac function will be needed to determine the exact mechanisms [ 46– 46].
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