The joint element between glucose sensing and insulin delivering actions is an automatic algorithm-based decision.
MCH neurons serve as an essential link between glucose sensing and sugar reward, and these data thus identify a key component of the neural circuit that establishes the preference for natural vs artificial sweeteners (Smiciklas-Wright et al., 2002; Jacobson, 2005; Domingos et al., 2011; Sicher, 2011).
In addition, a link between cellular glucose sensing and the Wnt/β-catenin pathway was recently reported in macrophages [3], indicating that this pathway could be inappropriately activated in diabetic hyperglycemic or obese subjects.
Furthermore, different diabetes research groups all over the world work on closing the loop between continuous glucose sensing and insulin delivery via insulin pumps (18– 20).
On the basis of these results, we discuss the future of in vivo tear glucose sensing and outline the studies needed to resolve the remaining questions about the relationship between tear and blood glucose concentrations.
Issad, T. & Kuo, M. O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity.
Flavine adenine dinucleotide-dependent glucose dehydrogenase has shown excellent selectivity toward glucose sensing and power supply application.
In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin secretion.
These gene sets pinpoint defects in mitochondrial electron transport, glucose utilization, and glucose sensing and reveal that they occur early in disease pathogenesis.
Rfx6 loss in adult β cells leads to glucose intolerance, impaired β cell glucose sensing, and defective insulin secretion.
The pancreatic enzyme GCK, which is responsible for glucose sensing, and the glucose transporter Glut-2, which initiates glucose-stimulated insulin secretion, were also expressed.
