Pairwise comparisons showed the genotype × sex interaction was due to male WT mice interacting more than GluN1hypo male mice [time spent socially interacting (mean ± SEM): WT 127.6 ± 11.2 s, GluN1hypo 72.1 ± 10.5 s; P < 0.001, Fig. 1a] but no difference between genotypes was seen in female mice (WT 51.6 ± 4.6 s, GluN1hypo 42.9 ± 4.7 s; P = 1.000, Fig. 1b).
Significant differences in the distribution of rs231775 (P<0.02), but not rs5742909 (P=0.21) or rs3087243 (P=0.49) genotypes were seen between cases and controls, and only rs231775 showed a significant association with RPL, with increments of 1.74 in disease risk seen for heterozygous carriers.
No significant differences in the severity of TDP-43 pathology scores between FTLD cases with TC and TT genotypes were seen for either frontal cortex (p = 0.301), temporal cortex (p = 0.592) or dentate gyrus of hippocampus (p = 0.768), or as total TDP-43 severity score (p = 0.519).
Multiple genotypes were identified within collections, and individual genotypes were seen in different collections.
For gene gene interactions, no significant difference in the frequencies of any combined genotypes was seen between patients with HCC and healthy controls.
However, a statistical significant difference in the distribution of genotypes was seen between current and former smokers (Table 1, Pearson's χ-test, 2 df, P<10−4).
In the study by Zubieta et al (2003) the correlation between pain sensitivity and genotype was seen first after a prolonged pain stressor.
Differences between male and female genotype effects were seen in five traits: taste panel assessed tenderness, weight of hindquarter, odour, sirloin weight after maturation and sirloin fat depth.
No significant genotype differences were seen [Genotype (Gen), P>0.05].
