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Although our focus was the association between genotype and expression in all smokers in the study, we also examined the difference in associations between SC and SNC groups.
Significant interaction between genotype and case-control status (F = 5.54, p = 0.0064) was found, indicating that the relationship between genotype and expression level differs between cases and controls.
Their work is motivated, as we are, by the recognition that correlation between genotype and expression does imply causality.
We also attempted to explore the links between genotype and expression of the exotoxins PSMα-3 (previously measured) and Hld.
The failure to identify correlation between genotype and expression may arise if the associated SNPs are in only modest LD with the true causal variants.
The complex dependence of the variations of gene expression regulation on phenotypic differences nurtures the expectation that important information can be gained from considering more subtle relationships between genotype and expression.
Similar(52)
Here we expand the investigation by collecting genes showing stringently determined cis-association between genotypes and expression phenotypes from major studies.
eQTL analysis: analysis of genomic loci that have statistically significant correlation between genotype and gene expression levels, and thus regulate gene expression levels.
Although global gene expression has been related to germline genetic variation, this relationship has been based on associations between genotype and gene expression in a single tissue type sampled across multiple individuals.
Drug-mediated effects on gene expression were investigated to elucidate a potential explanation for the observed differences in the relationships between genotype and gene expression among patients with and without IBD, respectively.
In the case of the intron genotype, the ordination of gene expression did not correspond to the two genotypes, corroborating the lack of statistical significance examined above between genotype and gene expression profiles.
More suggestions(16)
between genotype and prostate
between hypermethylation and expression
between genotype and risk
between description and expression
between genotype and response
between innovation and expression
between fact and expression
between disease and expression
between genotype and discharge
between utility and expression
between genotype and forage
between genotype and disease
between genotype and diet
between phenotype and expression
between genotype and chamber
between intention and expression
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