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We tested for significant association between gene sequence variation and gene expression variation at N = 30 candidate genes in DNA and RNA from N = 30 LCLs.
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We worked to characterize genetic sequence variants in lipid/sterol related genes in children affected with ASD to investigate the association between lipid/sterol gene sequence variation and neurodevelopmental phenotype that could identify new etiologies for ASD and eventually aid to focus intervention strategies.
We observed very strong correlations for all studied species between levels of gene content variation and levels of gene sequence variation.
One of the chief differences between the respective strains is the S-layer on their cell wall, which exhibits the SlpA gene and Cwp gene sequence variations.
We detected three QTL affecting in vivo virulence that were distinct from QTL affecting in vitro growth, and mapped the virulence QTL to regions containing 7 24 genes, excluding genes with no sequence variation between the parental strains and genes with only synonymous SNPs.
The causal link between sequence variation, gene expression, and phenotype arises because the polymorphism might be responsible for both a cis-eQTL and the QTL contributing to a quantitative phenotype, so called pQTL.
Genevar software was used to determine associations between sequence variation and gene expression (http://www.sanger.ac.uk/resources/software/genevar/) [ 7].
Summary: Genevar (GENe Expression VARiation) is a database and Java tool designed to integrate multiple datasets, and provides analysis and visualization of associations between sequence variation and gene expression.
In this model, between-gene variation, between-probe variation and between replicate are included.
We analyzed the gene on sequence variations and compared its expression in M. biceps femoris between healthy and affected piglets.
Gene expression is an intermediate phenotype that resides between DNA sequence variation and higher-level cellular or whole-body phenotypes including disease susceptibility and individualized drug response.
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