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This is consistent with our observation of a positive relationship between gene expression variability and GC3.
These functions indicate a potential relation between gene expression variability and the faster progression of this CLL subtype.
Partial correlations between gene expression variability and methylation and between GC3 and gene expression variability are much smaller than the full correlation coefficients.
There are strong relations between gene expression variability and disease subtype linking significantly increased expression variability to phenotypes such as aggressiveness and resistance to therapy in CLL.
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Specifically, we see a three-fold decrease in between-sample gene expression variability (based on standard deviation; Additional file 4) and improved between-brain reproducibility, as measured by between-brain correlation of differential expression across brain regions (detailed in next section; increase from R = 0.89 to R = 0.90; Additional file 4).
Finally, we found that genes showing higher between individual gene expression variability are enriched within these hypomethylated blocks.
> -wrap-foot> We compared full and partial correlation coefficients, calculated as in Kim and Yi (2007), between GC3, gene expression variability, and gene-body methylation (table 1).
Finally, the highly significant associations between basal gene expression variability and chemical-induced toxicity suggest plausible mode-of-action hypotheses for follow-up analyses.
Moreover, a significant correlation was observed between the extent of gene expression variability and the number of distinct miRNA targeting the 3′ UTR region.
In this work we demonstrate that there are strong relations between disease subtype and gene expression variability, suggesting an impact of gene expression variability on tumor adaptability and aggressiveness in CLL.
We detected 618 regions showing significant hypermethylation in U-CLL and 746 regions of hypomethylation in U-CLL, but could not find a direct relationship between DNA methylation and gene expression variability.
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