The comparative analysis about the gene expression, function, between human and mouse bidirectional genes were also performed and we observed that the selective force of this architecture doesn't derive from the co-regulation between paired genes, but the functional bias of bidirectional genes at whole genome level is observed strengthened during evolution.
In conclusion, by taking advantage of the slow evolutionary rates of chondrichthyian genomes, we were able to precisely compare the gene expression, function and regulation between pectoral fin and limb development, and discover a key difference between them.
Brinkmeier, H. TRP channels in skeletal muscle: gene expression, function and implications for disease.
My lab studies how the genomic sequences that control gene expression function and evolve.
Additionally, we also illustrate the disparity between gene expression and protein function in simple 2D culture modes, and that recreation of a physiologically mimetic 3D environment is necessary to induce both expression and function of cultured hepatocytes.
The 229 genes that were significantly up-regulated during biofilm growth included several genes previously implicated in biofilm development of S. Typhimurium, including curli, cellulose and genes required for motility [ 23, 24, 71], confirming the link between gene expression and gene function in our experiment.
Loss-of-function studies by RNAi and adoptive cell transfer may, thus, represent a new method to study direct correlations between gene expression and the function of the respective protein in an inflammatory response.
Despite the relationships between gene expression and protein function, further analysis, such as analysis of proteins, will be needed to clarify the influence of KCNQ1 and KCNH2 mRNA copy number on the etiology of LQTS.
RNA-seq analysis provides a powerful tool for revealing relationships between gene expression level and biological function of proteins.
