CMAP is a coarse-grained graphical modeling approach in which the system of interest is modeled as an interaction map between functional elements of the system, in a manner similar to portrayals of signaling pathways commonly used by molecular cell biologists.
Symbol "-|- designates primers located in linkers between functional elements within the domain.
RNA structure within introns can alter accessibility or distance between functional elements and thus regulate splicing [ 59].
This chapter describes IP-based protocols that are basis of communication between the various functional elements in the IP multimedia subsystem (IMS) architecture.
Of these 54 regions, 36 (67%) totally or partially overlapped with 58 RefSeq genes, indicating that the variation in CNV between population groups involves functional elements, in agreement with previous data, and indicating a significant relationship between the genomic regions affected by CNV and gene content [ 1, 3].
Here, we conducted a genome-wide systematic computational analysis of genomic architecture of lncRNAs, and further provided a more comprehensive comparative view of genomic organization between lncRNAs and several other functional elements in the human genome.
However, these findings were based on the global analysis of allelic variation detected in the one or few individuals selected for whole genome sequencing, and they thus do not address the question of the distribution of these structural variations within populations nor do they attempt to examine in detail the relation between such polymorphic insertions and functional elements in the genome.
Functional elements in mammalian gene promoters can be identified by high conservation between species distantly related on the evolutionary scale, particularly for genes with conserved function across different taxa [44], [45].
Having established the orthology of bidirectional promoters between human and mouse, we now shift our attention to the problem of discriminating functional elements in the human genome.
He led the analysis group for the ENCODE project, which is defining functional elements in the human genome.
