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There are several methods that search for paths or transitions between functional contexts in interactomes (e.g. Banks et al., 2008; Pandey et al., 2007).
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Second, combined approaches tend to partition the datasets, thereby establishing one-to-one correspondences between genes and functionalities although it is well-known that genes can participate in several functional contexts.
Since coloration is susceptible to alteration in various functional contexts, it usually lacks value as a conservative characteristic for determining systematic relationships between all but the most closely related species.
Although several classes of KDM1-selective small molecule inhibitors have been recently developed, these pan-active site inhibition strategies lack the ability to selectively discriminate between KDM1 activity in specific, and occasionally opposing, functional contexts within these complexes.
Overlapping modules reflect different functional contexts where genes being part of the overlap play a role in all contexts affected.
Any measure of the difference in biological age between HIV-infected and HIV-seronegative individuals will also have to be viewed in a functional context between these two groups, wherein differences in biochemical parameters, such as interleukin-6, CD14 and D-dimer, are also addressed [45].
Integrated proteogenomic analysis of this type can provide functional context to interpret genomic abnormalities in terms of cancer biology.
Pathways model relations in a specific functional context.
A deeper understanding of the relationships between functional genomics data across contexts is needed to identify the conditions in which mapping across contexts is justified.
To assess the relationship between different functional networks in the context of the HMM, we examined the relationship between the points in time at which different states are active.
One of the key issues in evolutionary contexts is the relationship between functional explanation ("teleology") and causal-mechanistic explanation (Wouters 2005).
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