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Although the lack of multiple testing corrections in array data is a limitation of this study, the similarities between functional classes of predicted and experimentally altered genes indicate perturbation of these functions by HIPPI in cells.
Thus, although we did not (and could not) test a continuum of sounds from one category to another, the proportion of responding sites and the magnitude of responses clearly differed between functional classes of songs and less within them.
Attempts have been made to discover an association between functional classes of genes and GC3.
We show that the contributions of tree-like and net-like evolutionary processes substantially differ across bacterial and archaeal lineages and between functional classes of genes.
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The relation between functional class of clusters and evolution in the positive selection mode on a tree branch was considered to be significant, if p < 0.05.
The structural relationships between different functional classes of GPCRs can be extremely distant.
Furthermore, there is a striking similarity between the functional classes of proteins affected by both aging and iron.
Our data suggest parallel evolution of biological sequences and expression levels (Fig. 3E) and also point out that the degree of purifying forces varies between distinct functional classes of sequences.
The transitions between functional classes suggest that the index does reflect the graduation of functional competence.
Moreover, levels of selective pressure were heterogeneous between functional classes and between species, with cold responsive genes evolving particularly fast in C. resedifolia, but not in C. impatiens.
Genes previously in class 4.0.0 have now transferred to a wide range of different functional classes including 'cell processes' (class 1.0.0), 'sporulation' (class 1.8.1), 'extrachromosomal' (class 5.0.0) and 'conserved hypothetical' (class 0.0.2) reflecting transitions between functional classes based on more accurate annotation tools and increasing numbers of C. difficile genomic studies.
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