This data is consistent with a number of early clinical studies, which demonstrate a correlation between structural and functional changes in IPF lungs [ 29, 30].
The exact mechanisms responsible for the increase in arterial stiffness in type 1 diabetes are not fully understood but are likely to reflect a complex interaction between structural and functional changes in the arterial wall.
Therefore, findings in the present study clearly point to functional changes beyond what can be explained by a mere shift in populations, and extend earlier observations of possible dissociations between structural and functional changes in obese individuals 29 30 or CD patients.
Alternatively, given the central role of the insula in multimodal processing, the connection between structural and functional changes in the insula and PTSD may be more complex and may touch on more facets of brain function than emotion identification and verbalization.
The aim of this study was threefold: to highlight the patterns of grey matter (GM) atrophy, hypometabolism and hypermetabolism in patients with ALS, then to understand the neurobehavioral significance of hypermetabolism and, finally, to investigate the regional differences between the morphologic and functional changes in ALS patients, using a specially designed voxel-based method.
The divergence in locomotor specialisation between these species may have elicited functional changes in the dynamics of hind limb muscle function.
The ratio of NAA to Cr were lower in patients with chronic hip pain, suggesting an association between chronic hip pain and functional changes in the thalamus.
Accumulated experimental evidence supports an association between obesity and morphological and functional changes in hearts of both humans [ 3– 6] and animals [ 7– 9].
To facilitate the design of clinical strategies to potentially prevent or reverse the age-related decline in learning and memory during menopause, the relationship between the estrogen-induced morphological and functional changes in hippocampus must be defined and the role these changes play in facilitating learning must be elucidated.
The most likely explanation for the rapid development of ExMV research, which has been followed by an exponential increase in the number of published papers in subsequent years, has been the demonstration that these small cellular membrane fragments transfer RNA species and several other biologically active molecules between cells and thus may induce functional changes in the target cells [13 15].
