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This difference is not so significant between functional categories in the intronic regions of the same genes.
We compared dN/dS between functional categories in conifers and gymnosperms, and consistently found higher dN/dS in conifers in most functional GO Slim categories.
In the same work, Kurth and colleagues propose that the presence of intrainsular connections and the evidence of overlap between functional categories in the anterior dorsal insula could be two possible ways of reasoning about how functional integration could be embodied in the insula.
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In A. gambiae as well as in Drosophila, the level of genetic diversity appeared to be similar between immune related genes and control genes and between functional categories of genes involved in immunity.
If synonymous mutations, and even more so mutations at 4D sites, follow a neutral mode of evolution, we would expect no significant difference in average μS between functional categories (Additional file 4).
Motivation: A major challenge in regulatory genomics is the identification of associations between functional categories of genes (e.g. tissues, metabolic pathways) and their regulating transcription factors (TFs).
The data in Table 2 suggest that the mean similarity scores differ between functional categories.
However, clusters can be characterized by two or three main functional categories, suggesting a good match between functional categories and expression profiles, except for clusters 3 and 6, which could not be related to a specific functional category.
Analysis of the divergently transcribed genes associated with a targeted set of bidirectional promoters is likely to lead to discovery of novel genes involved in development and/or previously undescribed relationships between genes of different functional categories in common or complementary processes/responses.
No significant difference (Pearson's Chi-squared test, Yate's continuity correction, p > 0.53) was observed between the frequency of COG functional categories in all nuwts or full-length nuwts when compared to those for wBm.
The observed large number (3322) of QTT and wide range of functional categories in thyroid suggest a close relationship between thyroid function and plasma ALT levels.
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Justyna Jupowicz-Kozak
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