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Conclusions There is an intra-class difference between fixed combinations of inhaled corticosteroid/long acting β2 agonist with regard to the risk of pneumonia and pneumonia related events in the treatment of patients with COPD.
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Fixed combinations of compliance and resistance were used to determine the different clinical conditions.
Inhalers for fixed combinations of ICS and LABA include pMDIs and DPIs.
In NL, off-label use was observed for the fixed combinations of ß2-mimetics + anticholinergics.
Use of the fixed combinations of short-acting SABA + ACH was low overall, but most frequent in Italy.
Patients using fixed combinations of ICS and LABA had their asthma control and spirometry assessed during regular visits.
Fixed combinations of ICS + LABA were infrequently used in young children but exceeded 1/100 PY in adolescents in the Netherlands.
Within the study period, the highest annual PPRs were found for budesonide (between 75.6 and 90.6 per 10,000 persons) and the fixed combination of salmeterol/fluticasone (between 62.1 and 73.1 per 10,000 persons).
All euros in all countries would be converted into a fixed combination of the two.
The first-line drug regimen used in Botswana is a fixed combination of Zidovudine, Lamivudine, and Nevirapine or Efavirenz [9].
Out of these patients, 99% received a fixed combination of LABA/ICS [ 25].
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