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However, we observed no significant differences in cell size and adipogenesis between fibroblasts derived from DLC2−/− and DLC2+/+ mice.
Several studies have reported differences between fibroblasts derived from healthy lung and IPF lung [ 9].
We have previously investigated the transcriptomic differences between fibroblasts derived from diseased DC cords versus fibroblasts from phenotypically normal palmar fascia in patients undergoing carpal tunnel (CT) release.
In addition, we observed differences in the levels of FGFR2 mRNA expression between fibroblasts derived from normal breast tissue or from tumor tissue, which strongly supports a holistic model to explain FGFR2-related breast cancer risk [ 45] rather than one assuming cell autonomous effects of FGFR2 expression modulation.
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Recent experimental studies implicate potentially important differences between cardiac fibroblasts derived from ventricular versus atrial tissue [ 18– 20].
Furthermore, Vasquez et al. [ 6] used a gap fluorescence recovery after photobleaching technique to show that intercellular coupling was enhanced between cardiomyocyte monolayers cocultured with cardiac fibroblasts derived from infarcted rat hearts compared to cardiac fibroblasts derived from normal hearts.
In order to receive further insight into the links between CS and IPF, we investigated pulmonary fibroblasts derived from IPF patients, in light of well-established features of senescent cells.
We found significant differences in invasiveness between these two populations in cocultures with primary fibroblasts derived from colon cancer tissues, especially in cocultures with fibroblasts positive for CD10, a membrane metalloendopeptidase.
Differentiation of fibroblasts derived from scar, adjacent and remote myocardium.
This observation was reproducible in fibroblasts derived from 4 additional donors (Supplementary Table 3).
Modulation of CD8+ CTL effector function by fibroblasts derived from the immunoprivileged cornea.
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