Regardless, in this study test set, we showed an inverse relationship between Pfetin expression and risk of recurrence.
Multivariate-adjusted proportional hazard regression models showed no association between protein expression and risk of death for any of the seven markers examined.
In order for this profile to be incorporated into clinical practice, it would be favorable to ascertain a mechanism that explains the association between gene expression and risk of death.
Nevertheless, this finding warrants confirmation in a longitudinal follow-up study of patients with oral leukoplakia lesions, to establish a possible link between nuclear S100A7 expression and risk of cancer development.
We also recognize the possible link between nuclear PTMA expression and risk of cancer development needs confirmation in a long term follow-up study of patients with squamous cell hyperplasia; such longitudinal studies are challenging but these patients are being followed up for regular monitoring of disease progression.
MCT1 has been reported to be upregulated in neuroblastoma cells, and elevated MCT1 mRNA levels have been detected in fresh neuroblastoma biopsy samples, with a positive correlation between expression level and risk of fatal outcome [ 77].
However, we were unable to single out a unique variant to explain the correlation between low BLK gene expression and risk alleles of SNPs in B1 and B3 due to the strong LD.
In order to visualize the relationship between direction of differential gene expression and risk of relapse, hierarchical clustering is used to arrange the matrix rows (genes), while the columns (patients) are ordered by increasing GEP70 risk score.
Initial analyses revealed a parabolic relationship between continuous measures of HER2 expression and risk of death, suggesting that the assumption of linearity for the HER2 expression measurements may be inappropriate in subsequent multivariate analyses.
These univariate analyses revealed a parabolic relationship between continuous measures of HER2 expression and risk of death, suggesting that the assumption of linearity for the HER2 expression measurements may be inappropriate in subsequent multivariate analyses.
