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2003-2004 SNCA triplication and duplication mutations demonstrate a dose-dependent relationship between expression and pathogenicity [ 58, 143- 146] that is now supported by several mouse models.
However, an even greater proportion of analog signature genes displayed these patterns, 81%, consistent with a correlation between expression and pathogenicity.
The highest-performing signature was expressed as a continuum in low-, medium-, and high-pathogenicity samples, suggesting a direct, analog relationship between expression and pathogenicity.
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Closer examination of the analog signature genes indicated a relationship between signature expression and pathogenicity.
Compelling evidence has revealed an association between virulence gene expression and pathogenicity in animal model.
The lines were tested for growth, antigen induced proliferation, cytokine production, V-beta 8.2 expression and pathogenicity.
Furthermore, the two-component systems PhoQ/PhoP and AstS/AstR have been shown to be involved in the regulation of mutualism and/or pathogenicity gene expression [ 27, 28], and are believed to be members of a putative complex regulation network that coordinates the switch between mutualism and pathogenicity [ 2].
We found consistency between VOC and pathogenicity based classification of microorganisms.
These results show consistency between VOC and pathogenicity based classification of microorganisms.
Two global regulators, HexA and Ner, appear to control the switch between mutualism and pathogenicity in P. luminescens [ 25, 26].
Such an insertion/deletion event may have an important role in transitions between commensalism and pathogenicity [ 45].
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