Such inferences are limited by existing knowledge of the link between expression and biological function and by the availability of directly comparable data sets in both species.
The relationship between integrin expression and function in pathologies is often contentious as comparisons between human pathological expression and expression in cell lines is difficult.
A similar close relationship between receptor expression and function is present in cardiomyocytes where the β2AR subtype increases inotropy and acts to inhibit certain apoptosis events in progressive heart failure when catecholamine levels are elevated [18].
Although correlation alone is insufficient to prove causation, the coordination between cyclic expression and function is highly suggestive that timing of transcription can regulate the timing of higher order biological processes.
Finally, we observed a correlation between Imp1 expression and function within the telencephalon: the phenotypes observed in Imp1 deficient mice were consistently more profound in the dorsomedial telencephalon, where Imp1 expression was high, than in the dorsolateral telencephalon, where Imp1 expression was low.
NIS-mediated radionuclide imaging and therapy has exciting potential as a safe and effective method of breast cancer diagnosis and treatment, and delineating factors underlying the discordance between NIS expression and function is critical in moving this modality into the practical realm.
Our results illustrate a complex interplay between lamin gene expression and function through evolution.
This study demonstrates a link between altered integrin expression and function in primary breast cancers predisposed to metastasize.
In order to identify any relation between the observed expression and function of the encoded genes, Pageman over-representation analysis was carried out [ 27].
