Sentence examples for between expression and copy from inspiring English sources

We also identified 21 regions of high amplitude copy number gain, in which 32 known protein coding genes showed a strong positive correlation between expression and copy number.

Of the 692 probesets tested (11 did not contain copy number probes), 219 (corresponding to 206 protein-coding genes) showed a strong positive correlation (r≥0.6) between expression and copy number.

It should be noted that the relationship between expression and copy number is complex, and that the absence of significant correlations does not exclude the presence of the CNA, especially in cases where the low count of genes or samples makes this correlation statistically difficult to prove.

Depending on the modification of the regulatory landscape of specific genes, it has been shown that CNVs can affect distant transcripts in cis or in trans, and even result in a negative correlation between expression and copy number (more copies, less expression) [38].

Several explanations could accommodate for the discrepancies between expression and copy numbers.

Conversely, we discovered that 8% of CNVs were dosage reversed which exhibited negative associations between expression and copy number in homozygotes.

As a comparison, the relationship between expression and copy-number alterations for PTEN was typically associated with both heterozygous and homozygous deletions.

No significant differences were identified in the strength of the correlations between expression and genomic copy number in the different subtypes and in differentiated vs non-differentiated tumours.

High throughput single-nucleotide polymorphism (SNP) genotyping was performed on independent samples (n = 14) using Affymetrix GeneChip Mapping 100 K arrays to assess correlation between expression and gene copy number.

Correlation between expression and gene copy number of different patients was measured separately for each gene (identified based on the Affymetrix probe set).

Tumour expression of p16/p14ARF mRNA was heterogeneous and although there was no correlation between expression and CDKN2A copy number (P=0.35; ANOVA with t-test), homozygous deletion of the CDKN2A gene (samples 07/01, 27/02, 04/03 and 36/05) resulted in loss of p16/p14ARF mRNA expression.