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Twelve subjects participated in experiments on three days with a minimum interval between experimental days of one week.
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The salinity (ppt) of the 100% seawater varied between experimental days owing to the condition of the sea near the water intake.
The primary end-points were changes over time in relative BOLD response after infusion of CGRP or placebo, difference in BOLD response between two experimental days, difference in BOLD response before and after sumatriptan administration and between experimental days.
There was no difference in resting triplet torque or MVC between experimental days and average values across days are presented.
We found no difference in activated voxels or recordings of COPE1 values between two experimental days (P = 0.49) (Fig. 2c).
Calculation of sample size was based on the detection of a difference in headache intensity between two experimental days, at 5% significance with 90% power.
The proportion of cows responding with other types of leg movements did not differ between the experimental days.
We found no statistical difference between two experimental days (P = 0.357).
We found no statistical after sumatriptan between two experimental days (P = 0.49).
b Second level analysis revealed no statistical difference between two experimental days.
There were no significant differences between scores on the pre-drug testing of the different experimental days and none of the ANOVAs showed a main effect or "order" effect, or an interaction effect between "testing occasion" and "order of drug administration".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com