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Current knowledge points toward possible genetic link between endothelial dysfunction and DCS (Brubakk et al. 2007).
An association between endothelial dysfunction and arterial stiffness has recently been shown (Wilkinson et al., 2002b).
In this review, we will focus on the link between endothelial dysfunction and diabetic nephropathy.
Despite enormous research effort, the causal relationship between endothelial dysfunction and hypertension has remained unclear.
We did not find any relationship between endothelial dysfunction and O2∙−.
Moreover, the relationship between endothelial dysfunction and the presence of cardiovascular risk factors may be two-way.
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More and more papers in recent literature emphasize the relevant link between endothelial dysfunction, atherosclerosis and APS [12, 13, 14].
The endothelium is critically involved in the pathology of multiple diseases, in which there exist a well established association between endothelial dysfunction and/or damage and poor outcome [ 8, 9, 20- 24].
19, 24 Nonetheless, a study by Nystrom et al in patients with coronary artery disease revealed a correlation between endothelial dysfunction (measured with FMD) and the levels of CRP. 25 The different inclusion criteria among these studies may account for the observed discrepancies regarding the relationship between FMD and CRP.
Females with history of gestational diabetes mellitus (GDM) are of particular interest for studying the relationship between endothelial dysfunction, impaired insulin sensitivity and cardiometabolic disorders, as this high risk entity represents the earliest stage of a prediabetic condition suffering from an increased risk for developing type 2 diabetes [ 9] but also CVD [ 10, 11].
The possible link between endothelial dysfunction, red blood cell function and pathological rheology and hemostasis may, in part, connect micro- and macrovascular complications with diabetes mellitus.
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