Sentence examples for between drug toxicity and from inspiring English sources
This article addresses the problem of designing therapies for the myeloma bone disease that optimize in a systematic way a compromise between drug toxicity and tumor repression.
We demonstrate that optimal growth does not coincide with maximum induction of the mar promoter, but instead results from the interplay between drug toxicity and mar induction.
They also raise an interesting question: do trade-offs between drug toxicity and resistance also play a role in inducible drug resistance?
Here we combine experiments with a simple phenomenological model to fully characterize a range of effects resulting from the trade-off between drug toxicity and the benefit mediated by efflux pumps.
Irinotecan is used to treat rhabdomyosarcoma and refractory solid tumors, and the high association between drug toxicity and genetic variation in UGT1A1 has resulted in an FDA-mandated label change [ 29].
To study the trade-off between drug toxicity and induced resistance, we first measured the effects of salicylate and two protein synthesis inhibitors, chloramphenicol and tetracycline, on cell growth.
Here, we use the well-studied multiple antibiotic resistance (MAR) system in E. coli to experimentally characterize the trade-off between drug toxicity ("cost") and drug-induced resistance ("benefit") mediated by efflux pumps.
Immediate diagnosis of sepsis in critical conditions of cancer patients can be complicated due to the similarity between the manifestations of drug toxicity and systemic infectious complications.
An aspect that is not covered here, however, is that fast switching between regimens (<60 days) could increase drug toxicity and may lead to bad adherence to therapy.
The cellular response to a combination of such chemical stressors may be governed by a trade-off between the fitness costs due to drug toxicity and benefits mediated by inducible systems.
Prolonged treatment is associated with drug toxicities and a risk of viral resistance.
