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If transmission is sustained for a longer period, the time interval between doses should be increased.
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Antipsychotic monotherapy is generally recommended, and most guidelines converge on a recommendation that doses should be between 300 and 1000 chlorpromazine equivalents [ 5] in order to achieve the important goal of maximum reduction of positive symptoms, while avoiding EPS and use of anticholinergic medication [ 6].
This is true for doses between zero and 240 mg/L, and extrapolating to higher doses should be done with caution.
Doses should be as low as possible.
Doses should be rounded liberally.
How many doses should be used?
Perioperative corticosteroids stress doses should be given.
Occupational doses should be analyzed by each department; high doses and outliers should be investigated.
Also, although a predefined dose-transition schedule was utilized in this current study, because of differences in bioavailability between products, MTS dose should be titrated based on individual response when patients are switched from oral ER-MPH formulations.
For maintenance, the recommended dose should be between 300 and 600 mg/day (CPZ equivalents) (recommendation n° 4).
When radiotherapy is proposed, the dose should be between 45 and 54 Gy (standard, level of evidence: B2).
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