Later in the book, Kistiakowsky, who was a nuclear expert and veteran of the Manhattan Project, wrote: "… a linear relation between dose and effect… I still believe is entirely unnecessary for the definition of the current radiation guidelines, since they are pulled out of thin air without any knowledge on which to base them".
The prevailing theory is that the relationship between dose and effect is linear – that is, that if a big dose is bad for you, half that dose is half that bad, and a quarter of that dose is one-quarter as bad, and a millionth of that dose is one-millionth as bad, with no level being harmless.
There was an inverse correlation between dose and effect: significantly greater effects were observed with the 20-mg dose compared with 60 mg.
Increases in sCD25 and decreases in circulating lymphocytes mediated by IL-21 showed a positive correlation between dose and effect.
The significant inter-individual variation in dose response suggests that the relationship between dose and effect in the postoperative period is complicated.
The dynamics of this effect are time dependent and the relationship between dose and effect is best characterised by AUC MIC ratio [59].
However, it's exclusion from the analysis did not result in a relationship between dose and effect size difference, and therefore this study remained in the meta-analysis.
The wide therapeutic index of targeted agents, non-linear relationship between dose and effect and non-mechanism related toxicity may require definition of an optimal biological dose rather than a maximal tolerated dose (MTD).
On the contrary, when dealing with the effectiveness of interventions, a dose-response gradient is often lacking, e.g. drug treatments may not exhibit a linear relationship between dose and effect (22).
If hemofiltration would remove the drug we would expect higher drug concentrations in group 1 with the lower CVVH, and assuming a linear relation between dose and effect, also a higher anti-Xa activity.
