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Collectively the recent articles by Borrell-Pages et al, Yan et al, and Gschwind et al. demonstrate that ADAMs are important regulators of EGFR ligand shedding and EGFR activation in tumour cells, also contributing to the productive "cross-talk" between diverse signalling pathways and EGFR.
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Mechanisms governing the inflammatory response during sepsis involve crosstalk between diverse signaling pathways, but current knowledge provides an incomplete picture of the syndrome.
Finally, evidence presented here and previous results by others suggest that the regulation of CRT retrotranslocation by calcium could be a crossroad between diverse signaling pathways.
ARNT, on the contrary, appears to be a common dimerization partner for many nuclear transcription factor proteins [ 53- 58], most probably playing the role of crosstalk integrator between diverse signaling pathways.
Borrell-Pages et al. [ 1] establish relevance of TACE to TGFα shedding and EGFR signalling in clinical breast cancer, while Gschwind et al. [ 2] and Yan et al. [ 3] reveal that TACE and ADAM10 contribute to the interplay between EGFR and diverse signalling pathways.
For instance, palmitoylation regulates localization and signalling activity of Ras isoforms, and hence diverse signalling pathways [9].
Endocytosis is a key regulatory step of diverse signalling pathways, including receptor tyrosine kinase (RTK) signalling.
T3SS effectors are targeted to different subcellular compartments and affect diverse signalling pathways and physiological processes.
Activated EGFR triggers diverse signalling pathways in tumour cells (Ahmed et al, 2006; Yarden and Shilo, 2007).
The extensive physical interaction between Rbf1 and components of diverse signaling pathways suggests a novel means by which cell-cycle information may be integrated with the information related to metabolic status, organ and tissue size, and differentiation states.
The differences between these cells may be the result of a more robust activation of diverse signaling pathways activated by CXCR4 and the use of insensitive Gα chain used by CXCR4.
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