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In many cases, we now have laboratory crossing and molecular evidence for hybridization or introgression (Additional File 2) Most hybrids recorded here are between distinct forms that overlap substantially in their distributions, and are therefore generally considered different species.
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C. trachomatis undergoes a biphasic developmental cycle alternating between two distinct forms: the infectious elementary body (EB), and the replicative but non-infectious reticulate body (RB).
Interconversion between the distinct forms occurs spontaneously, albeit slowly on the time scale of minutes.
Until recently, however, less attention had been given to the mechanisms governing the choice between two distinct forms of growth arrest: quiescence, where cells enter a reversible non-cycling state, and senescence, an irreversible loss of proliferative potential that is coupled with specific changes in cell morphology and gene expression.
You cannot move gradually between two topologically distinct forms – say a bagel and a Swedish pretzel (see video).
All chlamydial species share a unique biphasic developmental cycle in which the chlamydiae alternate between two morphologically distinct forms.
We also studied the distribution of genotypes between the two distinct forms of PE, the early-onset, placental and the late-onset, maternal form [29].
MiR-145 may contribute to the differences in epigenetic background between the two distinct forms of antiestrogen resistance.
The interchange between functionally and morphologically distinct forms implies tight control of gene expression during the life cycle of the parasite [ 3].
To characterize the relationship between the genome-wide binding of distinct forms of RNAPII and mRNA abundance, we calculated the Pearson's Correlation Coefficient (PCC or r) between the dynamic RNAPII occupancy (p <0.05 and 1.5 fold change) and the expression levels of corresponding mRNAs.
They are fundamentally distinct forms.
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